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Serum concentrations of modafinil might be reduced to some clinically important extent from the presence of medicines that induce CYP3A4. These incorporate rifampin, phenytoin, St John Wort, and efavirenz.
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Elimination: The elimination 50 percent-life of only one dose in healthier subjects is close to 15 hrs.[eighteen] Extreme renal and/or hepatic impairment is known to bring about substantially elevated constant-point out drug concentrations. Dose reduction is recommended in clients with serious hepatic impairment.
The effects of modafinil on hormonal contraceptives occurs if the hormones are taken by mouth, patch, or implant.
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Do not get started, halt, or change the dosage of any drugs in advance of checking with your health care provider, health and fitness care service provider or pharmacist 1st.
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This medication comes along with a Medication Guide. It is vital that you simply examine and realize this information and facts. Be sure you ask your health practitioner about something you do not have an understanding of.
Your healthcare company may check you carefully if you have experienced a the latest coronary heart assault or have chest soreness affiliated with little if any exercise. Stop having modafinil and obtain crisis assistance right away.
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The influence of alcohol on modafinil hasn't been sufficiently evaluated. Liquor probably really should be avoided though having modafinil.